The Role of Thyroid Function Tests
Thyroid function testing can be used in several ways, including:
- Diagnosis – this testing aims to find the cause of symptoms. Thyroid function testing can reveal whether the thyroid gland is functioning normally or abnormally and what specific disorder you may have.
- Screening – this is testing for disease in the absence of symptoms. All newborns in the U.S. are routinely screened for an underactive thyroid. Some adults may also be screened for thyroid disorders, although not all experts agree that this is beneficial.
- Monitoring – thyroid blood tests provide valuable information about whether treatment for thyroid disorders is working as it should or if it needs adjustment.
Who should get testing?
Thyroid function testing is often ordered when patients have symptoms of a thyroid disorder. Testing can assist with diagnosing or ruling out thyroid problems as a cause of your symptoms.
Many of the symptoms of common thyroid problems are nonspecific; there is a wide range of diseases and disorders which may cause them. Thyroid function testing, which may be referred to as a full thyroid panel, complete thyroid panel, extended thyroid panel or other thyroid lab tests, may be included with other tests to evaluate if you are having trouble with a non-specific symptom like fatigue, depression, or difficulty becoming or staying pregnant.
In addition to being used for diagnosis, thyroid function tests may be performed to screen for thyroid disease in patients who have no symptoms. Newborn infants are routinely screened for hypothyroidism shortly after birth.
Screening for thyroid disease in adults is controversial. Some experts recommend screening certain groups who are at higher risk of having an underactive thyroid. These risk factors may include:
- Age
- Family history of thyroid disease
- Personal history of type I diabetes
- Personal history of autoimmune disease
- Personal history of radiation to the head and neck
Other experts do not recommend routine screening for thyroid disorders in adults. The U.S. Preventive Services Task Force, which issues screening recommendations, has concluded that there is currently not enough evidence to assess the benefits and drawbacks of screening for thyroid disorders.
Thyroid function tests are also used for treatment monitoring. Patients with known thyroid disorders will have periodic thyroid function testing to ensure their treatment is effective.
Best Overall Thyroid Function Test
Let’s Get Checked Thyroid Antibody Test
Price: $119
Type: At-home collection
Sample: Blood
Tests for: TSH, free T3, free T4, thyroid peroxidase antibodies
Results timeline: 2 to 5 days
The Let’s Get Checked Thyroid Function Test is designed for self-collection at home and requires a simple finger prick. Detailed instructions are included with your order, as is a prepaid shipping label for mailing your sample to a CLIA-certified Let’s Get Checked lab. This test measures:
- Thyroid-stimulating hormone: TSH for short, this hormone produced in the pituitary gland regulates production of the T3 and T4 hormones. Since it’s a sensitive marker, TSH is often used to screen for thyroid diseases and conditions.
- Free T3: Triiodothyronine is produced in the thyroid gland and considered most active of the two main thyroid hormones. Free T3 levels fluctuate due to overactive or underactive thyroid glands.
- Free T4: In addition to T3, T4 is the other main thyroid hormone. Fluctuating T4 levels are strong indicators of an overactive or underactive thyroid gland.
- Thyroid peroxidase antibodies: These antibodies bind to thyroid enzymes, affecting thyroid production in the process. Increased antibody levels can be indicators of conditions such as Hashimoto’s thyroiditis and Graves’ disease.
Your test results come in the form of a personalized report. If a thyroid condition is detected, you may speak with a physician via an online consultation. Prescription options are also available through Let’s Get Checked.
Types of Thyroid Function Tests
A number of blood tests may be used to screen for and diagnose thyroid disorders. Below are some thyroid function tests that may be used for screening and diagnosis:
More Thyroid Function Tests
Getting Thyroid Function Testing
Thyroid function tests are typically ordered by a primary care physician, endocrinologist, or another medical professional. These tests are most often performed in a doctor’s office, clinic, medical lab, hospital, or another medical setting.
Costs of thyroid testing
The cost of a thyroid test will vary by location and test type. Some clinics, usually community or nonprofit clinics, offer free or low-cost testing. Labs, clinics, and at-home testing companies may accept insurance to cover or lower your cost of testing. If you order you own thyroid lab tests, that could impact the cost of testing as well. As for how much blood work for thyroid costs without insurance, that depends on your testing facility.
Types of sample collection
A blood sample is required for a thyroid panel test. If you’re giving a sample in a lab, expect a blood draw. At home, you’ll fill in blood spots.
Getting test results
Typically, your doctor will interpret several thyroid function test results along with your symptoms and health history to determine whether a thyroid disorder is present.
It often takes a few business days before the results of your thyroid function test(s) are available. You may receive the results by mail or through an online health portal, or your doctor may schedule an appointment to review the results with you and discuss the next steps.
Sources
A.D.A.M. Medical Encyclopedia. Fatigue. Updated April 26, 2019. Accessed October 3, 2022.https://medlineplus.gov/ency/article/000317.htm
A.D.A.M. Medical Encyclopedia. Antithyroglobulin antibody test. Updated January, 2021. Accessed October 3, 2022.https://medlineplus.gov/ency/article/003557.htm
A.D.A.M. Medical Encyclopedia. Infertility. Updated January 26, 2020. Accessed October 3, 2022. https://medlineplus.gov/ency/article/001191.htm
A.D.A.M. Medical Encyclopedia. Toxic nodular goiter. Updated January 26, 2020. Accessed October 3, 2022.https://medlineplus.gov/ency/article/000317.htm
A.D.A.M. Medical Encyclopedia. Simple goiter. Updated January 27, 2020. Accessed October 3, 2022.https://medlineplus.gov/ency/article/001178.htm
A.D.A.M. Medical Encyclopedia. Thyroid function tests. Updated July 2, 2021 Accessed October 3, 2022. https://medlineplus.gov/ency/article/003444.htm
A.D.A.M. Medical Encyclopedia. Thyroid nodule. Updated July 2, 2021. Accessed October 3, 2022. https://medlineplus.gov/ency/article/007265.htm
American Society of Clinical Oncology. Guide to thyroid cancer. Updated January 2021. Accessed October 3, 2022.https://www.cancer.net/cancer-types/thyroid-cancer
American Thyroid Association. Thyroid function tests. Date unknown. Accessed October 3, 2022.https://www.thyroid.org/thyroid-function-tests/
American Thyroid Association. Thyroid nodules. Date unknown. Accessed October 3, 2022.https://www.thyroid.org/thyroid-nodules/
ARUP Consult. Initial evaluation of thyroid function.Updated February 2021. Accessed October 3, 2022.https://arupconsult.com/content/initial-evaluation-thyroid-function
Columbia Surgery. At-home thyroid testing kits: What we know…and what we don’t: An interview with Dr. Hyesoo Lowe. Columbia Surgery website. Date unknown. Accessed October 3, 2022.https://columbiasurgery.org/news/home-thyroid-testing-kits-what-we-knowand-what-we-dont
Davies TF. Pathogenesis of Hashimoto’s thyroiditis (chronic autoimmune thyroiditis). In: Ross DS, ed. UpToDate. Updated January 3, 2020. Accessed October 3, 2022.https://www.uptodate.com/contents/laboratory-assessment-of-thyroid-function
LaFranchi S. Clinical features and detection of congenital hypothyroidism. In Geffner ME, ed. UpToDate. Updated April 9, 2021. Accessed October 3, 2022. https://www.uptodate.com/contents/clinical-features-and-detection-of-congenital-hypothyroidism
Lyness JM. Unipolar depression in adults: Assessment and diagnosis. In Roy-Byrne PP, ed. UpToDate. Updated December 28, 2020. Accessed October 3, 2022.https://www.uptodate.com/contents/unipolar-depression-in-adults-assessment-and-diagnosis
National Institute of Diabetes and Digestive and Kidney Diseases. Hyperthyroidism (overactive thyroid). Updated August 2016. Accessed October 3, 2022.https://www.niddk.nih.gov/health-information/endocrine-diseases/hyperthyroidism
National Institute of Diabetes and Digestive and Kidney Diseases. Thyroid tests. Updated May 2017. Accessed October 3, 2022.https://www.niddk.nih.gov/health-information/diagnostic-tests/thyroid
National Institute of Diabetes and Digestive and Kidney Diseases. Hypothyroidism (underactive thyroid). Updated March 2021. Accessed October 3, 2022.https://www.niddk.nih.gov/health-information/endocrine-diseases/hypothyroidism
Ross DS. Laboratory assessment of thyroid function. In: Cooper DS, ed. UpToDate. Updated December 11, 2019. Accessed October 3, 2022.https://www.uptodate.com/contents/laboratory-assessment-of-thyroid-function
Ross DS. Diagnosis of hyperthyroidism. In: Cooper DS, ed. UpToDate. Updated April 19, 2021. Accessed October 3, 2022.https://www.uptodate.com/contents/diagnosis-of-hyperthyroidism
Ross DS. Patient Education: Hypothyroidism (underactive thyroid) (Beyond the basics) In: Cooper DS, ed. UpToDate. Updated April 20, 2021. Accessed October 3, 2022.https://www.uptodate.com/contents/hypothyroidism-underactive-thyroid-beyond-the-basics
U.S. Preventive Services Task Force. Thyroid dysfunction: Screening. Published May 24, 2015. Accessed October 3, 2022.https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/thyroid-dysfunction-screening